4-Méthoxy-6-[(E)-2-(4-méthoxyphényl)éthènyl]-2H-pyran-2-one
yangonin
CAS: 500-62-9
Molecular Formula: C15H14O4
4-Méthoxy-6-[(E)-2-(4-méthoxyphényl)éthènyl]-2H-pyran-2-one - Names and Identifiers
4-Méthoxy-6-[(E)-2-(4-méthoxyphényl)éthènyl]-2H-pyran-2-one - Physico-chemical Properties
| Molecular Formula | C15H14O4 |
| Molar Mass | 258.27 |
| Density | 1.325 g/cm3 |
| Melting Point | 155-157° |
| Boling Point | 487.6±45.0 °C(Predicted) |
| Flash Point | 219.8°C |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Vapor Presure | 1.18E-09mmHg at 25°C |
| Appearance | Yellow green powder |
| Color | Pale Yellow to Pale Green |
| BRN | 230710 |
| Storage Condition | 2-8°C |
| Stability | Light Sensitive |
| Refractive Index | 1.577 |
| MDL | MFCD00221733 |
| Physical and Chemical Properties | It is soluble in methanol, ethanol, DMSO and other organic solvents, and is derived from the root of kava pepper Piper methylsterum Forst. |
| In vitro study | Yangonin is one of the six major kavalactones found in Piper methysticum .Yangonin potently inhibits NF-κB activation through suppression of the transcriptional activity of the RelA/p65 subunit of NF-κB. Yangonin significantly inhibits the induced expression of the NF-κB-reporter gene. However, Yangonin does not interfere with TNF-α-induced inhibitor of κBα (IκBα) degradation, p65 nuclear translocation, and DNA-binding activity of NF-κB. Yangonin inhibits not only the induced NF-κB activation by overexpression of RelA/p65, but also transactivation activity of RelA/p65. Yangonin does not inhibit TNF-α-induced activation of p38, but it significantly impairs activation of ERK 1/2 and stress-activated protein kinase/JNK. |
4-Méthoxy-6-[(E)-2-(4-méthoxyphényl)éthènyl]-2H-pyran-2-one - Risk and Safety
| WGK Germany | 3 |
4-Méthoxy-6-[(E)-2-(4-méthoxyphényl)éthènyl]-2H-pyran-2-one - Reference Information
| use | methoxy pepper is a lactone isolated from Piper methysticum. The active ingredients of the kava are a set of ca. The 18 compounds are collectively called kava lactone or kava piroone. Kava lactone, dihydrokava lactone, methyl kava lactone, dihydromethyl kava lactone, methoxy pepper and demethoxy pepper are the six main types of kava lactone. Kava drinks and other preparations are considered anti-anxiety and are used to treat anxiety disorders. Dietary supplements containing kava shrub roots have involved several cases of liver toxicity in people, including several who needed liver transplants after using kava supplements. Inhibit contraction of airway smooth muscle, anti-arthritis, antiasthmatic. used for content determination/identification/pharmacological experiment, etc. |
| Biological activity | Yangonin has high affinity for human recombinant cannabinoid CB1 receptor, IC50 and Ki are 1.79 μM and 0.72 μM respectively. |
Last Update：2024-04-09 15:16:50
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Spot supply
Product Name: Yangonin Visit Supplier Webpage Request for quotationCAS: 500-62-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Yangonin Visit Supplier Webpage Request for quotationCAS: 500-62-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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